Mid ka mid ah wargeysyada ugu dambeeyay ee ku saabsan antioxidant-kan awoodda badan waa dib u eegis lagu daabacay Cilmi-baarista Daaweynta Jirka bishii Maarso 2019, kaas oo dib u eegay 9 shay oo ku saabsan saameynta quercetin ee cudurka dheef-shiid kiimikaadka Tijaabo la xakameeyey oo aan kala sooc lahayn.

Cudurka dheef-shiid kiimikaadka waxaa loola jeedaa dhibaatooyin caafimaad oo taxane ah oo kordhiya halista sonkorowga nooca 2aad, cudurrada wadnaha, iyo istaroogga, oo ay ku jiraan dhiig kar sare, sonkorta dhiigga oo sareysa, heerarka triglyceride oo sareeya, iyo dufanka dhexda ku urursan.

In kasta oo daraasado dhammaystiran ay ogaadeen in quercetin uusan wax saameyn ah ku lahayn gulukooska dhiigga soonka, iska caabbinta insulin-ta ama heerarka hemoglobin A1c, haddana falanqayn kooxeed oo dheeraad ah ayaa muujisay in quercetin lagu kabay daraasado qaatay ugu yaraan 500 mg maalintii ugu yaraan siddeed toddobaad.” Sonkorta dhiigga soonka oo si weyn hoos ugu dhacday.

Quercetin waxay ka caawisaa nidaaminta muujinta hidda-wadaha

Sida laga soo xigtay daraasad la daabacay 2016, quercetin wuxuu sidoo kale kicin karaa kanaalka mitochondrial ee apoptosis (dhimashada unugyada ee la barnaamijiyay ee unugyada dhaawacan) isagoo la falgalaya DNA-da, taasoo keenta dib-u-noqoshada burooyinka.

Daraasado ayaa lagu ogaaday in quercetin uu kicin karo sunta unugyada leukemia, saameyntuna waxay la xiriirtaa qiyaasta. Saameyn xaddidan oo sunta cytotoxic ah ayaa sidoo kale laga helay unugyada kansarka naasaha. Guud ahaan, quercetin wuxuu kordhin karaa cimriga jiirka kansarka 5 jeer marka la barbar dhigo kooxda xakamaynta aan la daaweyn.

Qorayaashu waxay saameyntan ku sababeeyeen isdhexgalka tooska ah ee u dhexeeya quercetin iyo DNA-da iyo kicinta wadada mitochondrial ee apoptosis, waxayna soo jeedinayaan in isticmaalka suurtagalka ah ee quercetin oo ah daawo kaaliye u ah daaweynta kansarka uu mudan yahay sahaminta dheeraadka ah.

Daraasad dhowaan lagu daabacay joornaalka Molecules ayaa sidoo kale xoogga saartay saameynta epigenetic-ga ee quercetin iyo awooddeeda:

Isdhexgalka kanaalada calaamadaynta unugyada
Xakamee muujinta hidda-wadaha
Saameyn ku yeelo dhaqdhaqaaqa arrimaha qoraalka
Waxay nidaamisaa aashitada microribonucleic (microRNA)

Aashitada Microribonucleic waxaa mar loo arki jiray DNA "aan la cunin". Daraasado ayaa lagu ogaaday in DNA-da "aan la cunin" aysan waxba tarayn. Dhab ahaantii waa molecule yar oo ribonucleic acid ah, kaas oo door muhiim ah ka ciyaara nidaaminta hidda-wadaha sameeya borotiinka aadanaha.

Aashitada Microribonucleic waxaa loo isticmaali karaa "beddelka" hiddo-sidayaashan. Sida laga soo xigtay soo-gelinta aashitada microribonucleic, hiddo-siduhu wuxuu qarin karaa wax ka badan 200 oo badeecooyin borotiin ah. Awoodda Quercetin ee ay ku beddeli karto microRNA-yada ayaa sidoo kale sharxi karta saameynteeda sunta ah iyo sababta ay u muuqato inay kordhinayso badbaadada kansarka (ugu yaraan jiirarka).

Quercetin waa walax awood leh oo ka hortagta fayraska

Sida kor ku xusan, cilmi-baarista laga sameeyay quercetin waxay diiradda saareysaa awooddeeda ka hortagga fayraska, taasoo inta badan sabab u ah saddex farsamo oo ficil ah:

Joojinta awoodda fayrasyadu u leeyihiin inay ku faafaan unugyada
Jooji taranka unugyada cudurka qaba
Yaree iska caabbinta unugyada cudurka qaba ee daaweynta daawooyinka fayraska lidka ku ah

Tusaale ahaan, daraasad ay maalgelisay Waaxda Difaaca Mareykanka oo la daabacay 2007 ayaa lagu ogaaday in ka dib marka aad la kulanto walbahaar jireed oo aad u daran, quercetin ay yarayn karto khatartaada inaad qaaddo fayraska oo ay hagaajiso waxqabadkaaga maskaxda, haddii kale waxay dhaawici kartaa shaqadaada difaaca jirka, taasoo kaa dhigaysa mid u nugul cudurrada.

Daraasaddan, baaskiilleyda waxay heleen 1000 mg oo quercetin ah maalintii, oo ay weheliso fiitamiin C (kordhinta heerarka quercetin ee plasma) iyo niacin (kor u qaadista nuugista) shan toddobaad oo isku xigta. Natiijooyinka waxay ogaadeen in marka la barbardhigo kuwa aan la daaweyn Baaskiil kasta oo la daaweeyay, kuwa qaatay quercetin ay fursad aad u yar u lahaayeen inay qaadaan cudur fayras ah ka dib markii ay baaskiil wateen saddex saacadood maalintii saddex maalmood oo isku xigta. 45% dadka ku jira kooxda placebo way xanuunsadeen, halka 5% oo keliya dadka ku jira kooxda daaweynta ay xanuunsadeen.

Hay'adda Mashaariicda Cilmi-baarista Sare ee Difaaca Mareykanka (DARPA) ayaa maalgelisay daraasad kale, oo la daabacay 2008, waxayna baratay isticmaalka fayraska hargabka H1N1 ee aadka u faafa si loogu hortago xayawaanka lagu daweeyay quercetin. Natiijadu wali waa isku mid, xanuunka iyo dhimashada kooxda daaweynta ayaa si weyn uga hooseeyay kan kooxda placebo. Daraasado kale ayaa sidoo kale xaqiijiyay waxtarka quercetin ee ka dhanka ah fayrasyo ​​kala duwan, oo ay ku jiraan:

Daraasad la sameeyay 1985-kii ayaa lagu ogaaday in quercetin uu joojin karo caabuqa iyo taranka fayraska herpes simplex nooca 1aad, nooca poliovirus nooca 1aad, nooca 3aad ee fayraska parainfluenza, iyo fayraska isku-dhafka neefsashada.

Daraasad xayawaan oo la sameeyay sanadkii 2010 ayaa lagu ogaaday in quercetin uu joojin karo labada fayras ee hargabka A iyo B. Waxaa sidoo kale jira laba daahfur oo waaweyn. Marka hore, fayrasyadani ma yeelan karaan iska caabin quercetin; marka labaad, haddii lala isticmaalo daawooyinka fayraska ka hortaga (amantadine ama oseltamivir), saameyntooda si weyn ayaa loo kordhiyaa - horumarka iska caabintana waa laga hortagaa.

Daraasad xayawaan ah oo la sameeyay sannadkii 2004 ayaa lagu ansixiyay nooc ka mid ah fayraska H3N2, iyadoo la baarayo saameynta quercetin uu ku leeyahay hargabka. Qoraagu wuxuu tilmaamay:

"Marka uu jiro caabuqa fayraska hargabka, walbahaarka oksaydhka ayaa dhaca. Maadaama quercetin uu soo celin karo heerka antioxidants badan, dadka qaar waxay u maleynayaan inay tahay daawo wax ku ool ah oo ka ilaalin karta sambabada inay sii daayaan inta lagu jiro caabuqa fayraska hargabka. Saamaynta waxyeelada leh ee xagjirrada aan oksijiinta lahayn."

Daraasad kale oo la sameeyay 2016 ayaa lagu ogaaday in quercetin uu nidaamin karo muujinta borotiinka isla markaana uu saameyn difaac ah ku leeyahay fayraska hargabka H1N1. Gaar ahaan, nidaaminta borotiinka shoogga kulaylka, fibronectin 1 iyo borotiinka xannibaadda ayaa gacan ka geysta yareynta taranka fayraska.

Daraasad saddexaad oo la daabacay 2016 ayaa lagu ogaaday in quercetin uu joojin karo noocyo kala duwan oo hargabka ah, oo ay ku jiraan H1N1, H3N2, iyo H5N1. Qoraaga warbixinta cilmi-baarista ayaa aaminsan, "Daraasaddan waxay muujinaysaa in quercetin uu muujiyo dhaqdhaqaaq xakameyn ah marxaladda hore ee caabuqa hargabka, kaas oo bixiya qorshe daaweyn mustaqbalka ah oo suurtagal ah iyada oo loo marayo horumarinta daawooyin dabiici ah oo wax ku ool ah, ammaan ah, iyo kuwo jaban si loogu daaweeyo loogana hortago caabuqa fayraska [Influenza A].

Sannadkii 2014, cilmi-baarayaashu waxay tilmaameen in quercetin "uu u muuqdo mid rajo leh marka la daaweynayo hargabka caadiga ah ee ay keenaan fayrasyada rhinoviruses" waxayna ku dareen, "Cilmi-baaristu waxay xaqiijisay in quercetin uu yareyn karo gudaha iyo taranka fayrasyada in vitro. Jirku wuxuu yareyn karaa culeyska fayraska, oof-wareenka iyo jawaab celinta sare ee marinnada hawada."

Quercetin wuxuu sidoo kale yareyn karaa waxyeelada oksaydhka, taasoo yareyneysa khatarta caabuqyada bakteeriyada labaad, kuwaas oo ah sababta ugu weyn ee dhimashada la xiriirta hargabka. Waxaa muhiim ah, quercetin wuxuu kordhiyaa biosynthesis-ka mitochondrial ee murqaha lafaha, taasoo muujineysa in qayb ka mid ah saameyntiisa fayraska ay sabab u tahay calaamadda fayraska ee mitochondrial oo la xoojiyay.

Daraasad xayawaan oo la sameeyay sannadkii 2016 ayaa lagu ogaaday in quercetin uu joojin karo fayraska dengue iyo caabuqa fayraska hepatitis ee jiirka. Daraasado kale ayaa sidoo kale xaqiijiyay in quercetin uu awood u leeyahay inuu joojiyo caabuqyada hepatitis B iyo C.

Dhawaan, daraasad lagu daabacay joornaalka Microbial Pathogenesis bishii Maarso 2020 ayaa lagu ogaaday in quercetin uu bixin karo ilaalin dhammaystiran oo ka dhan ah caabuqa Streptococcus pneumoniae labadaba in vitro iyo in vivo. Sun (PLY) oo ay sii dayso pneumococcus si looga hortago faafitaanka caabuqa Streptococcus pneumoniae. Warbixinta "Microbial Pathogenesis", qoraagu wuxuu tilmaamay:

"Natiijooyinka waxay muujinayaan in quercetin uu si weyn u yareeyo dhaqdhaqaaqa hemolytic iyo sunta cytotoxicity ee ay keento PLY iyadoo la joojinayo sameynta oligomers."
Intaa waxaa dheer, daaweynta quercetin waxay sidoo kale yareyn kartaa dhaawaca unugyada ee PLY-dhexdhexaadka ah, waxay kordhin kartaa heerka badbaadada ee jiirarka qaba qiyaasaha dilaaga ah ee Streptococcus pneumoniae, waxay yareyn kartaa dhaawaca sambabada, waxayna joojin kartaa cytokines (IL-1β iyo TNF) ee dareeraha lavage-ka ee bronchoalveolar. -α).
Marka la eego muhiimadda ay dhacdooyinkani u leeyihiin cudurka 'streptococcus pneumoniae' ee u adkaysta, natiijooyinkayagu waxay muujinayaan in quercetin uu noqon karo musharax cusub oo suurtagal ah oo loogu talagalay daaweynta caabuqyada pneumococcal ee kiliinikada.
Quercetin wuxuu la dagaallamaa bararka wuxuuna xoojiyaa shaqada difaaca jirka

Marka laga soo tago firfircoonida fayraska, quercetin waxay sidoo kale xoojin kartaa difaaca jirka waxayna la dagaallami kartaa bararka. Daraasad 2016 lagu daabacay joornaalka Nutrients ayaa tilmaamtay in hababka ficilka ay ka mid yihiin (laakiin aan ku xaddidnayn) joojinta:

• Tumor necrosis factor alpha (TNF-α) oo ay keento lipopolysaccharide (LPS) ee macrophages. TNF-α waa cytokine ku lug leh bararka nidaamka. Waxaa soo daaya macrophages-ka firfircoon. Macrophages-ku waa unugyo difaac oo liqi kara walxaha shisheeye, noolaha yaryar iyo qaybaha kale ee waxyeelada leh ama dhaawacan.
• Heerarka mRNA-da TNF-α iyo interleukin (Il)-1α ee ay keento Lipopolysaccharide ee unugyada glial, kuwaas oo horseedi kara "hoos u dhaca unugyada neerfaha"
• Joojinta soo saarista enzymes-ka keena bararka
• Ka hortagga kaalshiyamka inuu galo unugyada, taasoo joojinaysa:
◦ Sii deynta cytokines-ka pro-bararka
◦ Unugyada mast-ka ee mindhicirku waxay sii daayaan histamine iyo serotonin 

Sida ku xusan maqaalkan, quercetin wuxuu sidoo kale xasilin karaa unugyada mast-ka, wuxuu leeyahay firfircooni ilaalin ah oo ku saabsan mareenka caloosha iyo mindhicirka, wuxuuna "leeyahay saameyn toos ah oo sharciyeyn ah oo ku saabsan astaamaha shaqada aasaasiga ah ee unugyada difaaca jirka", si uu "hoos u dhigo ama u joojiyo noocyo kala duwan oo kanaallo iyo shaqooyin barar ah," wuxuu joojiyaa tiro badan oo bartilmaameedyo molecular ah oo ku jira heerka fiirsashada micromolar".

Quercetin waxay noqon kartaa kabitaan waxtar u leh dad badan

Marka la eego faa'iidooyinka kala duwan ee quercetin, waxay noqon kartaa kabitaan faa'iido leh dad badan, ha ahaato dhibaatooyin degdeg ah ama kuwo muddo dheer socda, waxay yeelan kartaa saameyn gaar ah. Tani sidoo kale waa kabitaan aan kugula talinayo inaad ku haysato khaanadaha daawada. Waxay ku anfici kartaa marka aad dareento inaad ku dhowdahay inaad "ka buuxsanto" dhibaato caafimaad (ha ahaato hargab caadi ah ama hargab).

Haddii aad u nugul tahay hargabka iyo ifilada, waxaa laga yaabaa inaad tixgeliso inaad qaadato quercetin dhowr bilood ka hor xilliga hargabka iyo ifilada si aad u xoojiso habdhiska difaaca jirkaaga. Waqtiga dheer, waxay u muuqataa mid aad waxtar u leh bukaanada qaba cilladda dheef-shiid kiimikaadka, laakiin waa wax aad u nacasnimo ah in lagu tiirsanaado oo keliya kaabisyo gaar ah oo lagu guuldareysto in la xalliyo dhibaatooyinka aasaasiga ah sida cuntada iyo jimicsiga isku mar.