Waraaqihii ugu dambeeyay ee antioxidant-kan xoogga leh waxaa ka mid ah dib u eegis lagu daabacay Cilmi-baarista Phytotherapy bishii Maarso 2019, taas oo dib u eegtay 9 shay oo ku saabsan saameynta quercetin ee cudurka dheef-shiid kiimikaadka la kala soocay tijaabada la xakameeyey.

Cudurka dheef-shiid kiimikaadka waxaa loola jeedaa dhibaatooyin caafimaad oo taxane ah oo kordhiya halista nooca 2-aad ee sonkorowga, cudurada wadnaha, iyo istaroogga, oo ay ku jiraan dhiig karka, sonkorta dhiigga oo sarreeya, heerarka triglyceride sare, iyo ururinta baruurta dhexda.

In kasta oo daraasado dhammaystiran ay ogaadeen in quercetin aanay wax saamayn ah ku lahayn gulukoosta dhiigga ee soonka, iska caabbinta insulin ama heerarka hemoglobin A1c, falanqaynta koox-hoosaadka dheeraadka ah ayaa muujisay in quercetin lagu kabay daraasado qaatay ugu yaraan 500 mg maalintii ugu yaraan siddeed toddobaad. Sonkorta dhiigga soonka oo aad u yaraatay.

Quercetin waxay caawisaa habaynta muujinta hidda-wadaha

Sida laga soo xigtay daraasad lagu daabacay 2016, quercetin waxay sidoo kale kicin kartaa kanaalka mitochondrial ee apoptosis (dhimashada unugyada borotiinka ee unugyada dhaawacan) iyadoo la falgasha DNA-da, taas oo keenta dib u soo noqoshada burooyinka.

Daraasaduhu waxay ogaadeen in quercetin ay keeni karto cytotoxicity unugyada leukemia, saameyntuna waxay la xiriirtaa qiyaasta. Saamaynta cytotoxic xaddidan ayaa sidoo kale laga helay unugyada kansarka naasaha. Guud ahaan, quercetin waxay kordhin kartaa nolosha jiirarka kansarka 5 jeer marka la barbar dhigo kooxda kantaroolka aan la daweyn.

Qorayaashu waxay u sababeynayaan saameyntan isdhexgalka tooska ah ee u dhexeeya quercetin iyo DNA iyo kicinta dariiqa mitirka ee apoptosis, waxayna soo jeedinayaan in isticmaalka suurtagalka ah ee quercetin sida daawada adjuvant ee daaweynta kansarka ay mudan tahay sahaminta dheeraad ah.

Daraasad dhowaan lagu daabacay joornaalka Molecules ayaa sidoo kale xoogga saartay saameynta epigenetic ee quercetin iyo awoodda ay u leedahay:

La falgalka kanaalada calaamadaha unugga
Habbee muujinta hiddaha
Saamayn ku yeelashada hawsha qodobbada qoraalka
Wuxuu hagaajiyaa microribonucleic acid (microRNA)

Microribonucleic acid ayaa mar loo tixgeliyey "junk" DNA. Daraasaduhu waxay ogaadeen in DNA-da "junk" aysan macno lahayn. Dhab ahaantii waa unug yar oo ribonucleic acid ah, kaas oo door muhiim ah ka ciyaara nidaaminta hidda-socodka sameeya borotiinnada aadanaha.

Microribonucleic acid waxa loo isticmaali karaa sida "bedelka" hidde-sidayaashan. Marka loo eego gelinta microribonucleic acid, hidde-sidaha wuxuu ku qori karaa wax ka badan 200 oo badeecado borotiin ah. Awoodda Quercetin ee wax ka beddelka microRNA-yada ayaa sidoo kale laga yaabaa inay sharaxdo saameynteeda cytotoxic iyo sababta ay ugu muuqato inay kordhiso badbaadada kansarka (ugu yaraan jiirarka).

Quercetin waa maaddo awood leh oo ka hortagta fayraska

Sida kor ku xusan, cilmi-baarista lagu sameeyay agagaarka quercetin waxay diiradda saaraysaa awooddeeda fayraska, taas oo inta badan ay sabab u tahay saddex hab oo ficil ah:

In la joojiyo awoodda fayrasyadu ku qaadaan unugyada
Jooji taranka unugyada cudurka qaba
Iska yaree iska caabbinta unugyada cudurka qaba daaweynta fayraska

Tusaale ahaan, daraasad ay maalgalisay Wasaaradda Difaaca ee Maraykanka oo la daabacay 2007dii ayaa lagu ogaaday in ka dib marka aad la kulanto cadaadis jireed oo aad u daran, quercetin ay yarayn karto khatarta aad ku qaadi karto fayraska waxayna wanaajin kartaa waxqabadka maskaxdaada, haddii kale waxay dhaawici kartaa shaqadaada difaaca , taasoo kaa dhigaysa mid aad u nugul. cudurada.

Daraasaddan, baaskiilleydu waxay heleen 1000 mg quercetin maalintii, oo lagu daray fitamiin C (kordhinta heerarka quercetin plasma) iyo niacin (kor u qaadista nuugista) shan toddobaad oo isku xigta. Natiijadu waxay ogaatay in marka la barbar dhigo kuwa aan la daawayn Baaskiil kasta oo la daweeyay, kuwa qaatay quercetin ay si aad ah hoos ugu dhacday fursada uu ku qaadi karo cudurka fayraska ka dib markii ay baaskiil wateen saddex saacadood maalintii saddex maalmood oo isku xigta. 45% dadka ku jira kooxda placebo ayaa bukooday, halka kaliya 5% dadka kooxda daawaynta ku jira ay bukoonayeen.

Hay'adda Mashaariicda Cilmi-baarista Sare ee Difaaca Maraykanka (DARPA) ayaa maalgelisay daraasad kale, taas oo la daabacay 2008, waxayna daraasad ku samaysay isticmaalka fayraska hargabka ee H1N1 ee aadka u faafa si loola dagaallamo xayawaanka lagu daweeyo quercetin. Natiijadu wali waa isku mid, cudurada iyo dhimashada kooxda daawaynta ayaa aad uga hooseeya kuwa kooxda placebo. Daraasado kale ayaa sidoo kale xaqiijiyay waxtarka quercetin ee ka hortagga fayrasyada kala duwan, oo ay ku jiraan:

Daraasad la sameeyay 1985kii ayaa lagu ogaaday in quercetin ay joojin karto caabuqa iyo taranka fayraska herpes simplex nooca 1, dabaysha nooca 1, fayraska parainfluenza nooca 3, iyo fayraska syncytial neefsashada.

Daraasad xayawaan ah oo 2010 ah ayaa lagu ogaaday in quercetin ay joojin karto labadaba hargabka A iyo B. Waxa kale oo jira laba daahfur oo waaweyn. Marka hore, fayrasyadani ma yeelan karaan iska caabbinta quercetin; Marka labaad, haddii lala isticmaalo dawooyinka ka hortagga fayraska (amantadine ama oseltamivir), saameyntooda si weyn ayaa loo wanaajiyey - horumarinta caabbinta waa laga hortagayaa.

Daraasad xayawaan ah oo 2004 ah ayaa oggolaatay nooc ka mid ah fayraska H3N2, baadhista saamaynta quercetin ee hargabka. Qoraagu waxa uu tilmaamay:

"Inta lagu guda jiro infekshanka fayraska hargabka, diiqada oksaydhisku waxay dhacdaa. Sababtoo ah quercetin waxay dib u soo celin kartaa xoojinta antioxidants badan, dadka qaar waxay u maleynayaan inay noqon karto daawo wax ku ool ah oo ka ilaalin karta sambabada in la sii daayo inta lagu jiro caabuqa fayraska hargabka. Saamaynta waxyeellada leh ee oxygen-free radicals. "

Daraasad kale oo 2016 ah ayaa lagu ogaaday in quercetin ay nidaamin karto muujinta borotiinka waxayna leedahay saameyn difaac ah fayraska hargabka H1N1. Gaar ahaan, nidaaminta borotiinka shoogga kulaylka, fibronectin 1 iyo borotiinka xannibaadda ayaa caawiya dhimista fayraska.

Daraasad saddexaad oo la daabacay 2016 ayaa lagu ogaaday in quercetin ay joojin karto noocyo kala duwan oo hargab ah, oo ay ku jiraan H1N1, H3N2, iyo H5N1. Qoraaga warbixinta cilmi-baarista ayaa aaminsan, "Daraasaddani waxay muujinaysaa in quercetin ay muujiso waxqabadyada xannibaadda ee marxaladda hore ee caabuqa hargabka, taas oo bixisa qorshe daaweyn mustaqbalka ah iyada oo loo marayo horumarinta dawooyin dabiici ah oo waxtar leh, ammaan ah, oo aan qaali ahayn si loo daaweeyo loogana hortago [hargabka. Fayras] caabuq."

2014-kii, cilmi-baarayaashu waxay tilmaameen in quercetin "u muuqato rajo daawaynta hargabka caadiga ah ee ay keenaan rhinoviruses" waxayna raaciyeen, "Cilmi-baadhistu waxay xaqiijisay in quercetin ay yarayn karto gudaha iyo ku-noqoshada fayraska gudaha vitro. Jidhku waxa uu yarayn karaa culayska fayraska, oof wareenka iyo dareen-celinta hawo-mareenka."

Quercetin waxa kale oo ay yarayn kartaa waxyeelada oksaydhisku, taas oo hoos u dhigaysa halista infekshannada bakteeriyada labaad, kuwaas oo ah sababta ugu weyn ee dhimashada hargabka la xidhiidha. Muhiimad ahaan, quercetin waxay kordhisaa biosynthesis mitochondrial ee muruqa lafaha, taas oo muujinaysa in qayb ka mid ah saameynteeda fayraska ay sabab u tahay calaamadaha fayraska mitochondrial ee la xoojiyay.

Daraasad xayawaan ah oo 2016 ah ayaa lagu ogaaday in quercetin ay joojin karto fayraska dengue iyo fayraska cagaarshow ee jiirka. Daraasado kale ayaa sidoo kale xaqiijiyay in quercetin uu awood u leeyahay inuu joojiyo caabuqyada cagaarshowga B iyo C.

Dhawaan, daraasad lagu daabacay joornaalka Microbial Pathogenesis bishii Maarso 2020 waxay ogaatay in quercetin ay bixin karto ilaalin dhamaystiran oo ka dhan ah caabuqa Streptococcus pneumoniae labadaba gudaha vitro iyo in vivo. Sun (PLY) oo uu soo daayo pneumococcus si looga hortago faafitaanka caabuqa Streptococcus pneumoniae. Warbixinta "Wax-ka-hortagga Microbial", qoraagu wuxuu tilmaamay:

"Natiijooyinka waxay muujinayaan in quercetin ay si weyn u yareyso dhaqdhaqaaqa hemolytic iyo cytotoxicity ay keentay PLY iyadoo la xakameynayo sameynta oligomers.
Intaa waxaa dheer, daaweynta quercetin waxay sidoo kale yareyn kartaa dhaawaca unugyada PLY-dhexdhexaadinta, waxay kordhisaa heerka badbaadada ee jiirarka qaba qiyaasaha halista ah ee Streptococcus pneumoniae, waxay yareysaa dhaawaca sambabada ee sambabada, waxayna joojisaa cytokines (IL-1β iyo TNF) ee dheecaanka bronchoalveolar lavage. -α) sii deyn.
Iyadoo la tixgelinayo muhiimada dhacdooyinkan ee pathogenesis of Streptococcus pneumoniae adkeysiga, natiijooyinkayagu waxay muujinayaan in quercetin laga yaabo inay noqoto musharax cusub oo suurtagal ah daroogada daaweynta caabuqyada pneumococcal ee bukaan-socodka. "
Quercetin waxay la dagaalantaa caabuqa waxayna kordhisaa shaqada difaaca

Marka lagu daro dhaqdhaqaaqa fayraska, quercetin waxay sidoo kale kor u qaadi kartaa difaaca waxayna la dagaallami kartaa bararka. Daraasad 2016 ah oo lagu daabacay joornaalka Nutrients ayaa tilmaantay in hababka ficilku ay ka mid yihiin (laakiin aan ku xaddidnayn) joojinta:

• Tumor necrosis factor alpha (TNF-α) oo ay keentay lipopolysaccharide (LPS) ee macrophages. TNF-a waa cytokine ku lug leh bararka nidaamka. Waxa lagu qariyaa macrophages firfircoon. Macrophages waa unugyo difaaca oo liqi kara walxaha shisheeye, microorganisms iyo qaybaha kale ee waxyeelada leh ama dhaawacan.
• Lipopolysaccharide-ku-soo-baxa TNF-a iyo interleukin (Il) -1a mRNA heerarka unugyada glial, taas oo u horseedi karta "apoptosis unug neuronal ah oo hoos u dhaca"
• Jooji soo saarista caabuqa keena enzymes
• Ka ilaali kalsiyumku inay ku qulqulaan unugyada, si ay u joojiyaan:
◦ Siideynta cytokines pro-bararka
◦ Unugyada mastarada mindhicirka waxay sii daayaan histamine iyo serotonin 

Sida laga soo xigtay qodobkan, quercetin waxay sidoo kale xasilin kartaa unugyada mastarada, waxay leedahay hawlo cytoprotective ah oo ku saabsan mareenka caloosha iyo mindhicirka, iyo "waxay leedahay saameyn toos ah oo nidaamsan oo ku saabsan sifooyinka asaasiga ah ee unugyada difaaca jirka", si ay u "hoos u dejiso ama u horjoogsato noocyo kala duwan oo ah kanaalka caabuqa iyo hawlaha," Jooji tiro badan oo bartilmaameedyada molecular ee kala duwanaanshaha fiirsashada micromolar".

Quercetin waxay u noqon kartaa kab faa'iido u leh dad badan

Iyadoo la tixgelinayo faa'iidooyinka ballaaran ee quercetin, waxay noqon kartaa kabitaan faa'iido leh dad badan, haddii ay tahay dhibaatooyin degdeg ah ama waqti dheer, waxay yeelan kartaa saameyn gaar ah. Tani sidoo kale waa kabitaan aan kugula talinayaa inaad ku hayso golaha daawada. Waxay ku iman kartaa anfaca markaad dareento inaad ku dhowdahay in aad "ka badin" dhibaato caafimaad (haddii ay tahay hargab ama hargab caadi ah).

Haddii aad u nugul tahay inuu qaado hargab iyo ifilo, waxaa laga yaabaa inaad tixgeliso inaad qaadato quercetin dhowr bilood ka hor xilliga hargabka iyo hargabka si aad u xoojiso habka difaacaaga. Muddada dheer, waxay u muuqataa mid aad u faa'iido leh bukaanada qaba cilladda dheef-shiid kiimikaadka, laakiin waa wax aad u doqonnimo ah in lagu tiirsanaado oo keliya qaar ka mid ah supplements-ka oo ku guuldareystaan ​​inay xalliyaan dhibaatooyinka aasaasiga ah sida cuntada iyo jimicsiga waqti isku mid ah.