Kansarka sambabada ayaa ah nooca labaad ee ugu badan ee kansarka adduunka. Sanadka 2020, in ka badan 2.2 milyan oo qof oo adduunka oo dhan ah ayaa laga ogaan doonaa kansarka sambabada markii ugu horreysay. Isla sanadkaas, qiyaastii 1.8 milyan oo qof ayaa adduunka oo dhan u dhintay kansarka sambabada.
In kasta oo aan hadda la helin daawo loogu talagalay kansarka sambabada, haddana saynisyahannadu waxay ka shaqeynayaan fursadaha daaweynta. Qaar ka mid ah saynisyahannadan waxay ka shaqeeyaan Jaamacadda Teknolojiyadda Sydney (UTS), halkaas oo daraasad cusub ay muujisay in isku-darka dhirta dabiiciga ah ee loo yaqaan berberine uu joojin karo koritaanka unugyada kansarka sambabada ee shaybaarka.
Berberine waa isku-dhis dhireed dabiici ah oo loo isticmaali jiray daawada dhaqanka Shiinaha kumanaan sano. Waxaa laga helaa dhir kala duwan, oo ay ku jiraan barberry, goldenseal, canab Oregon, iyo turmeric geed.

(Alaabtayadu waaSoosaarka Berberine, si daacad ah u soo dhawoow su'aasha.)

Cilmi-baaris sannado badan socotay ayaa muujisay in berberine uu waxtar u leeyahay ka caawinta dadka qaba nooca 2aad ee sonkorowga inay nidaamiyaan heerarka sonkorta dhiiggooda waxayna ka caawin kartaa daaweynta cilladda dheef-shiid kiimikaadka.
Cilmi-baarayaashu waxay sidoo kale ogaadeen in berberine loo isticmaali karo daaweynta noocyo kala duwan oo kansarro ah, oo ay ku jiraan kansarka ugxan-sidaha, caloosha, iyo naasaha.
Sida laga soo xigtay Dr. Kamal Dua, oo ah bare sare iyo cilmi-baare sare oo ka tirsan Farmashiyaha Xarunta Cilmi-baarista ee Australia ee Daawada Dhammaystiran iyo Midaynta (ARCCIM), Jaamacadda Teknolojiyadda Sydney (UTS) iyo qoraaga hormuudka ka ah daraasadda, Berberine waxay hor istaagtaa laba geeddi-socod oo muhiim ah oo ku saabsan horumarinta kansarka - Fiditaanka iyo guuritaanka unugyada.
"Si farsamo ahaan, tan waxaa lagu gaari karaa iyadoo la joojiyo hiddo-sidayaasha muhiimka ah sida P53, PTEN iyo KRT18 iyo borotiinno sida AXL, CA9, ENO2, HER1, HER2, HER3, PRGN, PDGF-AA, DKK1, CTSB, CTSD, BCLX, CSF1. iyo CAPG oo la xiriira faafitaanka iyo socdaalka unugyada kansarka," ayuu sharraxay.
Daraasaddan hadda socota, koox cilmi-baaris ah oo ay ku jiraan Dr. Dua, Dr. Keshav Raj Paudel, Professor Philip M. Hansbrough iyo Dr. Bikash Manandhar oo ka tirsan UTS, iyo sidoo kale shaqaale ka socda Jaamacadda Caafimaadka Caalamiga ah ee Malaysia iyo Jaamacadda Al Qasim ee Sacuudi Carabiya, ayaa bartay sida berberine loogu isticmaali karo daaweynta kansarka sambabada.
"Isticmaalka caafimaad ee berberine waa mid xaddidan sababtoo ah milmidiisa liidata iyo helitaankiisa noolaha," ayuu sharraxay Dr. Dua oo u warramay MNT. "Hadafka ugu weyn ee daraasaddan waa in la hagaajiyo xuduudaha fiisikokimikada ee berberine iyadoo berberine loo beddelayo nanoparticles dareere ah oo crystal ah iyo in la sahamiyo awooddeeda ka hortagga kansarka in vitro ee unugyada asaasiga ah ee alveolar epithelial ee adenocarcinoma aadanaha A549."
Kooxda cilmi-baarista waxay sameeyeen nidaam daawo oo horumarsan oo ku daboolaya berberine meelo yaryar oo milmi kara oo baaba'aya. Nanoparticles-kan dareeraha ah ee kristal-ka ah ayaa loo isticmaalay in lagu daaweeyo unugyada kansarka sambabada ee aadanaha gudaha shaybaarka.
Dhammaadkii daraasadda, kooxdu waxay ogaatay in berberine uu gacan ka geystay joojinta soo saarista noocyada oksijiinta ee falcelinta leh, kiimikooyinka bararka leh ee ay soo saaraan unugyada qaarkood si ay uga jawaabaan duullaanka bakteeriyada iyo dhacdooyinka kale ee walaaca leh ee dhaawici kara unugyada.
Intaa waxaa dheer, berberine wuxuu ka caawiyaa nidaaminta hiddo-sideyaasha la xiriira walbahaarka oksaydhka iyo bararka, wuxuuna ka caawiyaa yareynta gabowga unugyada ee dhicis ah.
"Waxaan tusnay in, iyadoo la adeegsanayo hab nanotechnological ah, sifooyinka isku-dhafka ah la horumarin karo si wax looga qabto arrimo kala duwan oo la xiriira milmida, qaadashada unugyada, iyo waxtarka daaweynta," ayuu sharraxay Dr. Dua. Suurtagalnimada Ka-hortagga Kansarka Nanoparticles-keena dareeraha ah ee berberine waxay muujiyeen isla dhaqdhaqaaqa shan jeer qiyaasta marka la barbar dhigo suugaanta la daabacay, taasoo si cad u muujinaysa faa'iidooyinka nanodrugs-ka."
Si loo sii tijaabiyo natiijooyinkan, Dr. Dua wuxuu sheegay inuu qorsheynayo inuu isticmaalo madal cilmi-baaris cusub si uu u sameeyo daraasado qoto dheer isagoo adeegsanaya moodooyinka xayawaanka ee kansarka sambabka kahor.
"Daraasado dheeraad ah oo ku saabsan dawooyinka farmashiyaha iyo ka hortagga kansarka ee berberine nanodrugs ee moodooyinka xayawaanka ee vivo ayaa laga yaabaa inay muujiyaan faa'iidooyinkooda suurtagalka ah ee daaweynta kansarka sambabada oo ay u beddelaan qaabab qiyaaseed oo daaweyn ah," ayuu sharraxay.
"Marka aan xaqiijinno awoodda ka hortagga kansarka ee daawooyinka berberine ee noocyada xayawaanka ee kahor kiliinikada, tallaabada xigta waxay noqon doontaa in loo gudbo tijaabooyin caafimaad, kuwaas oo aan horeyba uga wada hadalnay shirkado badan oo Sydney ah," ayuu yiri Dr. Dua.
Intaa waxaa dheer, Dr. Dua wuxuu sheegay in awoodda berberine ee ka hortagga soo noqoshada kansarka sambabada loo baahan yahay in la xaqiijiyo: "In kasta oo aynaan weli baarin tan, waxaan qorsheyneynaa inaan ku darno daraasadaha mustaqbalka, waxaana sidoo kale aaminsanahay in nanoforms-ka berberine ay muujin doonaan waxqabad rajo leh."
Dr. Osita Onuga, oo ah dhakhtar qalliinka laabta iyo kaaliyaha bare sare oo ka tirsan qalliinka laabta ee Machadka Kansarka ee St. John ee Xarunta Caafimaadka ee Providence St. John ee Santa Monica, California, ayaa u sheegtay MNT in marka cilmi-baarayaashu ay helaan fursado cusub oo lagu daweeyo laguna hortago kansarka, ay had iyo jeer jirto rajo:
"Berberine waa qayb ka mid ah daawada Bariga, sidaa darteed dhaqan ahaan uma isticmaalno daawada Galbeedka. Waxaan u maleynayaa inay xiiso leedahay sababtoo ah waxaan eegeynaa waxa aan ognahay inay faa'iidooyin u leeyihiin daawooyinka Bariga, waxaanan ku darnaa cilmi-baaris si aan uga caawinno in loo turjumo daawada Galbeedka."
"Had iyo jeer waa wax rajo leh, laakiin waxay ku jirtaa shaybaarka, wax badan oo aan ka helno shaybaarkana daruuri ma aha inay horseedaan in bukaannada la daweeyo," ayuu sii raaciyay Onuga. "Waxaan u maleynayaa in waxa xiga ee la sameeyo ay tahay in la sameeyo tijaabooyin caafimaad oo ku saabsan bukaanada oo la ogaado qiyaasta."
Dadka qaar waxay la kulmaan calaamado qarsoon oo kansarka sambabada ah marxaladaha hore ee cudurka. Akhriso si aad wax badan u barato, oo ay ku jirto goorta aad dhakhtar la tashanayso.
Kansarka sambabka wuxuu ku dhacaa heerar kala duwan dumarka iyo ragga, laakiin astaamaha iyo arrimaha khatarta ah waa isku mid. Halkan waxaan ku sharxeynaa suurtagalnimada hidde-side iyo hormoon…
Waxaan nahay shirkad xirfadle ah oo soo saarta budada laga soo saaro dhirta, waan ku soo dhaweyneynaa inaad noo soo dirto su'aalo kasta oo ku saabsan badeecadeenna, waxaana leenahay saaxiib mas'uul ah oo xallin kara dhibaatooyinkaaga ku saabsan iibka kahor iyo iibka kadib. Nala soo xiriir wakhti kasta!!!