Waa maxay Shikimic acid?

Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) waa unug dabiici ah oo si dabiici ah u soo baxa kaas oo ah dhexdhexaad muhiim u ah biosynthesis ee lignin, amino acids aromatic (phenylalanine, tyrosine iyo tryptophan), iyo inta badan. dhirta iyo alkaloids microbial.

Shikimic acid waxaa caadi ahaan loo isticmaalaa sidii walxo bilow ah oo loogu talagalay isku dhafka warshadaha ee daawada fayraska oseltamivir (daawoyinka ka hortagga H5N1 fayraska hargabka ee loo isticmaalo daaweynta iyo ka hortagga dhammaan noocyada fayraska hargabka ee la yaqaan). Isku-dubaridka (-) zeylenone ee ku salaysan Shikimic Acid ayaa lagu soo warramey in si weyn loogu isticmaalo wakiilka kemotherabi kansarka. Xogta ayaa laga helayaa isku-dhafka monopalmitoyloxy Shikimic Acid, kaas oo leh firfircoonida xinjirowga lidka ku ah oo awood u leh in uu yareeyo xinjirowga dhiigga marka lagu maamulo gudaha muruqyada. Koox cilmi baaris ah oo Shiinees ah ayaa soo saartay Shikimic Acid derivative, triacetyl Shikimic Acid, kaas oo muujiya xinjirowga lidka ku ah iyo waxqabadka antithrombotic.

Intaa waxaa dheer, soosaarayaasha Shikimic Acid waxay muujiyeen xiisaha weyn ee beeraha iyadoo qaar badan oo iyaga ka mid ah loo isticmaalo sida herbicides iyo wakiilada antimicrobial sababtoo ah waxay xannibi karaan waddada Shikimic Acid ee dhirta iyo bakteeriyada iyada oo aan si xun u saameynin naasleyda.

Sidaa darteed, Shikimic Acid waxaa loo isticmaali karaa fal-celis ahaan isku-dhafka organic labadaba sayniska aasaasiga ah iyo codsiyada caafimaadka ee kimistariga organic iyo daawada, gaar ahaan diyaarinta daawooyinka kala duwan.

Sida maaddo kiimiko ah oo muhiim ah, shikimic acid ayaa lagu dabaqi karaa daaweynta cudurro badan:

1. Bakteeriyada iyo burooyinka

Sanadkii 1987, culimada Japan waxay ogaadeen in analoogga glioxalase I inhibitor ee methyl anthranilate ay leedahay saameyn cad oo xakameyn ah oo ku saabsan xariiqda unugyada Hela iyo Escheri ascites carcinoma, waxay sii dheereyn kartaa wakhtiga badbaadada ee jiirarka oo lagu tallaalay unugyada leukemia L1210, iyo suntu waa mid aad u hooseeya. Saameynteeda xakameyntu waxay inta badan la xiriirta falcelinta hydride sulfur. 1988, culimada Shiinaha waxay leeyihiin 1988, culimada Shiinaha waxay sameeyeen derivative shikimic acid waxayna caddeeyeen in xaruntani ay leedahay saamaynta joojinta unugyada leukemia L1210 ee vitro.

2. Anti-thrombosis

Saamaynta shikimic acid iyo waxyaabaha ka soo baxa ee nidaamka wadnaha iyo xididada ayaa lagu muujiyay doorka ka hortagga xinjirowga dhiigga iyo joojinta isku-darka platelet. Cilmi-baaristu waxay muujinaysaa in: shikimic acid ay leedahay saameyn xooggan oo ka hortag ah oo ku saabsan heerka isku-darka platelet-ka ee adenosine diphosphate-induced halbowlaha dhexe ee halbowlaha maskaxda ee jiirka; cirbadeynta xididada iyo muruqa ee shikimic acid waxay ka dhigi kartaa wakhtiga xinjirowga dhiigga ee jiirarka mid dheer.

3.Anti-cerebral ischemia

Shikimic acid iyo kuwa ka soo jeeda waxay leeyihiin saamaynta hagaajinta ischemia cerebral, inta badan hoos u dhigista mugga walaxda maskaxda ka dib markii xudunta ischemia cerebral ee jiirka, yaraynta dhibcaha shaqada neerfaha, yaraynta heerka bararka maskaxda, kordhinta socodka dhiigga maskaxda ee aagga ischemic iyo tilmaamayaasha kale. Daraasadaha qaarkood ayaa muujiyay in ka-soo-saarkeedu ay yareyn karaan heerka isku-darka erythrocyte-ka iyo in la xakameeyo isku-darka platelet ka dib ischemia cerebral, sidaas darteed fududeynta microcirculation maskaxda.