RutinCaanaha kiimikaad waa (C27H30O16 • 3H2O), fiitamiin, waxay leedahay saamaynta yaraynta qulqulka xididada iyo jajabnaanta, ilaali oo soo celisa bartinimada caadiga ah ee xididada. Kahortagga iyo daaweynta dhiig-baxa maskaxda ee hypertensive; Dhiigbaxa isha ee sonkorowga iyo dhiigbaxa dhiigbaxa ayaa sidoo kale loo isticmaalaa sida antioxidants-ka cuntada iyo midabada.

Waxa loo qaybiyaa afar qodob oo kala ah:

1. Rutin NF11: budada jaalaha ah-cagaaran, ama crystal acicular aad u fiican; Aan ur lahayn, dhadhamin; Midabku wuxuu ku madoobaa hawada; Kuleylka ilaa 185-192 ℃, wuxuu noqdaa jir jalatin ah oo brown ah wuxuuna ku qudhmi karaa qiyaastii 215 ℃. In yar oo ku milma ethanol, wax yar oo biyo karkaraya ku milmaya, aad u yar oo biyo qabow ku milmaya, si fudud ugu milmi kara khamriga isopropyl iyo methanol, aan milmin trichloromethane, ether iyo benzene; Ku milmay xalalka alkali hydroxide. Habka aqoonsiga waa A: hydrochloric acid reflux hydrolysis ilaa quercetin, kaas oo barta dhalaalkeedu yahay 312 ℃B: roobka koobabka cas. C: Ku darida xalalka sodium hydroxide waa orange jaale D: xal ethanol iyo ferric chloride xal waa cagaar brown E: xal ethanol leh hydrochloric acid iyo magnesium si tartiib tartiib ah content cas: ≥95.0% (UV) (by alaabta qalalan)

Miisaanka qallalan: 5.5% ~ 9.0%

Hadhaaga gubanaya ≤0.5%

Chlorophyll ≤0.004%

Midabka cas ≤0.004%

Walaxda la xidhiidha quercetin ≤5.0%(UV)

Tirada guud ee bakteeriyada aerobic ≤103cfu/g

Wadarta tirada caaryada iyo khamiirka ≤102cfu/g

Escherichia coli waa inaan la ogaan karin /g

Xaaladaha kaydinta Ku kaydi weel hawo-mareen ah oo ka fog iftiinka.

2. Rutoside Trihydrate EP 9.0: budo jaale ama jaale-cagaaran. Ku dhawaad ​​biyo, ku milma methanol, wax yar ku milmi kara ethanol (96%), ku dhawaad ​​aan lagu milmi karin methylene chloride. Ku milma xalka hydroxide. Habka aqoonsiga waa sida soo socota: A: nuugista ugu badan ee 257nm iyo 358nm, iyo ugu badnaan nuugista 358nm waa 305 ~ 330 Cabbirku wuxuu ka soo muuqan doonaa booska u dhigma ee chromatogram ee sheyga tixraaca D: xal ethanol leh hydrochloric acid iyo zinc ayaa muujin doona casaan.

Waxyaabaha ay ka kooban tahay 95.0% ~ 101.0% (wax qallalan) (titration)

Qoyaanka 7.5% ~ 9.5% (Cartesia)

Hadhaaga gubanaya ≤0.1%

Qiimaha nuugista iftiinka ugu badan ee wasakhda indhaha ee 450nm ilaa 800nm ​​waa in aanu ka weynayn 0.10

Maaddada aan milmi karin ee methanol ≤3.0%

Walaxda la xidhiidha isoquercetin ≤2.0%, kaempferol-3-rutin ≤2.0%, quercetin ≤2.0%, wadarta wasakhda ≤4.0%(HPLC)

Tirada guud ee bakteeriyada aerobic ≤104cfu/g

Wadarta tirada caaryada iyo khamiirka ≤102cfu/g

Bakteeriyada bile gram-negative ≤102cfu/g

Escherichia coli waa inaan la ogaan karin /g

Salmonella lagama yaabo in la ogaado /25g

Xaaladaha kaydinta waxay ka fogaadaan iftiinka

3. Rutin USP43: Habka aqoonsiga waa A: nuugista ugu badan ee 257nm iyo 358nm, iyo ugu badnaan nuugista 358nm waa 305 ~ 33. B: Muuqaalka nuugista infrared waa inuu la socdaa chromatogramka alaabta tixraaca. C: Waqtiga haynta ee chromatogram-ka ugu sarreeya waa inuu ahaadaa mid la mid ah kan sheyga tixraaca

Waxyaabaha ay ka kooban tahay 95.0% ~ 101.0% (wax qallalan) (titration)

Qoyaanka 7.5% ~ 9.5% (Cartesia)

Hadhaaga gubanaya ≤0.1%

Qiimaha nuugista iftiinka ugu badan ee wasakhda indhaha ee 450nm ilaa 800nm ​​waa in aanu ka weynayn 0.10

Maaddada aan milmi karin ee methanol ≤3.0%

Walxaha la xidhiidha isoquercetin ≤2.0%, kaempferol-3-rutin ≤2.0%, quercetin ≤2.0%, mono-kala duwan ≤1.0%, wadarta wasakh ≤4.0% (HPLC)

Tirada guud ee bakteeriyada aerobic ≤104cfu/g

Wadarta tirada caaryada iyo khamiirka ≤103cfu/g

Escherichia coli waa inaan la ogaanin /10g

Salmonella waa in aan la ogaan /10g

Xaaladda kaydinta waa la xidhay oo laga fogeeyay iftiinka.

4. Heerka Wasaaradda WS1-49(B) -89 ee Rutinum: budada jaalaha ah ama jaalaha ah-cagaaran, ama crystal acicular aad u fiican; Aan ur lahayn, dhadhamin; Midabku wuxuu ku madoobaa hawada; Kuleylka ilaa 185 ~ 192 ℃ si uu u noqdo jel brown. In yar oo ku milmay ethanol karkaraya, wax yar ku milmay biyo karkaraya, aad u yar oo biyo qabow ku milmaya, aan lagu milmin trichloromethane iyo ether; Ku milmay xalalka alkali hydroxide. Habka lagu aqoonsanayo waa: A: osaydh-ku-socod cas cas. B: Habka nuugista infrared-ka waa in uu ahaado mid la mid ah kan walaxda xakamaynta. C: Nuugista ugu badan waxaa laga helaa mawjadaha dhererka 259 ± 1nm iyo 362.5 ± 1nm.

Waxyaabaha ay ka kooban tahay ≥93.0%(UV)(wax qallalan)

Miisaanka qallalan oo luma 5.5% ~ 9.0%

Hadhaaga gubanaya ≤0.3%

Walaxda aan milmi karin ee methanol ≤2.5%

Walaxda la xidhiidha quercetin ≤4.0% (lakab khafiif ah)

Tirada guud ee bakteeriyada aerobic ≤103cfu/g

Wadarta tirada caaryada iyo khamiirka ≤102cfu/g

Escherichia coli waa inaan la ogaan karin /g

Salmonella waa inaan la ogaan karin /g

Xaaladda kaydinta waa la xidhay oo laga fogeeyay iftiinka.

Saamaynta dawooyinka:

Falka xagjirka ah ee xorta ah

Unugyada Ogsajiinta waxaa lagu dhimaa qaab hal elektaroonig ah oo ku jira dheef-shiid kiimikaadka unugyada, iyo Oions-yada ay ka dhashaan dhimista molecules oxygen-ka ee qaab elektaroonig ah waxay markaas soo saari doonaan H2O2 iyo sun aad u sareysa jilicsanaanta iyo xitaa dardargelinta gabowga maqaarka. Intaa waxaa dheer, ku darida rutin ee alaabta waxay si cad u tirtiri kartaa noocyada ogsijiinta ee ay soo saaraan unugyada. Rutin waa unug ka kooban flavonoid, kaas oo ah antioxidant xoog leh oo ka soo horjeeda xagjirnimada xorta ah. Waxay joojin kartaa falcelinta silsiladda ee xagjirnimada xorta ah, waxay joojisaa peroxidation ee acids dufanka polyunsaturated ee biofilms, ka saarta alaabta lipid peroxidation, waxay ilaalisaa daacadnimada biofilms iyo qaabdhismeedka unugyada hoose, waxayna door muhiim ah ka ciyaaraan jirka. [2]

Anti-lipid peroxidation

Lipid peroxidation waxa loola jeedaa tixanaha habab oksaydhaynta oo ay sababaan noocyada ogsijiinta fal-celiska ah ee aysiidhka dufanka badan ee polyunsaturated ee biofilms. Zhu Jianlin iyo al. la go'aamiyay oo la falanqeeyay dhaqdhaqaaqa SOD ee jiirka, waxa ku jira badeecada lipid peroxidation ee xorta ah ee MDA, iyo waxa ku jira Lipofuscin ee beerka weyn, oo la ogaaday in rutin uu saameyn joojin ku yeeshay peroxidation lipid ee jiirka la tuuray, oo uu joojin karo hoos u dhaca awoodda antioxidant. ee nidaamka antioxidant ee jiirka ka dib markii la tuuray. Rutin wuxuu iska caabin karaa hoos u dhaca awoodda antioxidant ee ay keento hoos u dhaca estrogen-ka endogenous wuxuuna leeyahay saameyn antioxidant. Lipoprotein cufnaanta sare (HDL) waxay leedahay saameyn lid ku ah atherosclerotic. Si kastaba ha ahaatee, HDL, sida lipoprotein cufnaanta hoose (LDL) iyo lipoprotein cufnaanta aadka u hooseeya (VLDL), sidoo kale waa la oksaydheyn karaa oo wax laga beddeli karaa gudaha vitro. Marka HDL ay oksaydhaysan tahay oo loo beddelo Ox-HDL, waxay leedahay saamaynta atherosclerosis. Meng Fang iyo al. baadhay saamaynta rutin ee HDL wax ka beddelka oksaydhka ee Cu2+ dhexdhexaadinta wax ka beddelka oksida ee vitro. Gabagabo Rutin wuxuu si weyn u joojin karaa wax ka beddelka oksaydhka ee HDL. [2]

Saamaynta lidka ku ah ee kicinta platelet

Cudurrada cudurrada wadnaha iyo xididdada dhiigga ee badan, sida xinjirowga dhiigga, atherosclerosis, falcelinta bararka iyo ischemia-reperfusion dhaawac bilaash ah, waxay si dhow ula xiriiraan dhexdhexaadinta plateletactivatingfactor (PAF). Sidaa darteed, ka-hortagga saameynta PAF waa hab muhiim ah oo lagu yareeyo cudurrada wadnaha iyo xididada ischaemic. Tijaabooyinku waxay muujiyeen in rutinku uu ka soo horjeedo xidhitaanka gaarka ah ee PAF ee soo-dhoweynta xuubka xuubka xuubka bakaylaha diiradda-ku-tiirsanaanta, waxay joojisaa ku-xidhnaanta PAF-dhexdhexaadinta platelet ee bakaylaha iyo korodhka Ca2 + lacag la'aanta ah ee PMNs, taas oo soo jeedinaysa in habka ficil-celinta anti-PAF ee rutin uu yahay si loo joojiyo firfircoonida soo-dhoweynta PAF, ka dibna la joojiyo falcelinta ay keentay PAF, si ay door uga ciyaaraan ilaalinta wadnaha iyo xididdada. Natiijooyinka waxay muujiyeen in rutin uu ahaa PAF antagonist. [2]

Anti-ba'an pankreatit

Rutin waxay si wax ku ool ah uga hortagi kartaa hypocalcemia waxayna yareyn kartaa Ca2+ diiradda unugyada ganaca. Waxaa la ogaaday in rutin uu kordhin karo maadada phospholipase A2 (PLA2) ee unugyada ganaca ee jiirka, taas oo soo jeedinaysa in rutin uu joojin karo sii deynta iyo firfircoonida PLA2 ee unugyada ganaca. Rutin ayaa si wax ku ool ah uga hortagi karta in ay dhacdo hypocalcemia ee jiirka AP, laga yaabo inay ka hortagto qulqulka Ca2 + iyo yaraynta culeyska Ca2 + ee unugyada unugyada ganaca, taas oo yareyneysa dhaawaca cudurada AP. [2]

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Wixii rutin ah, fadlan nala soo xiriir. Waanu kugu sugaynaa halkan wakhti kasta.